Quietum Plus is generally safe for most users, as it is formulated with natural ingredients that are widely well-tolerated. However, some individuals may experience mild side effects, such as gastrointestinal discomfort, headaches, or mild allergic reactions, especially if they are sensitive to any of the components. It is always advisable to consult a healthcare professional before starting use, particularly if you have pre-existing health conditions or are taking other medications, to avoid potential interactions.